Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 8/20 | 0.78 |
| ▸ | PDE4A | P27815 | 7/20 | 0.78 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.78 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.78 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418919 | 0.92 | PDE4A (0.82) | PDE4DPDE4APDE4BPDE4CABCB1 | |
| SCHEMBL7425188 | 0.88 | PDE4A (1.00) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7424700 | 0.85 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4CABCB1 | |
| SCHEMBL7422958 | 0.83 | PDE4A (0.69) | PDE4DPDE4APDE4BPDE4CABCB1 | |
| SCHEMBL7416808 | 0.80 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4CMAPK1 | |
| SCHEMBL7420807 | 0.79 | PDE4D (0.65) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7425474 | 0.77 | PDE4A (0.68) | PDE4DPDE4APDE4BPDE4CMAPK1 | |
| SCHEMBL7419413 | 0.76 | PDE4A (0.93) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7420702 | 0.76 | PDE4A (1.00) | PDE4DPDE4APDE4BPDE4CALDH1A1 | |
| SCHEMBL7418296 | 0.74 | PDE4A (0.74) | PDE4DPDE4APDE4BPDE4CABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |