Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.68 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420239 | 0.84 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DHIF1A | |
| SCHEMBL7425188 | 0.81 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL7416075 | 0.77 | PDE4D (0.78) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL7418919 | 0.77 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL7428268 | 0.76 | HTT (0.65) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL7417274 | 0.75 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DHIF1A | |
| SCHEMBL7423813 | 0.75 | PDE4D (0.61) | PDE4APDE4BPDE4CPDE4DMAPK1 | |
| SCHEMBL7422958 | 0.75 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL7416808 | 0.75 | PDE4D (0.73) | PDE4APDE4BPDE4CPDE4DHIF1A | |
| SCHEMBL7420807 | 0.74 | PDE4D (0.65) | PDE4APDE4BPDE4CPDE4DMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |