Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 7/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 7/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 7/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419413 | 0.96 | PDE4A (0.93) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7417394 | 0.89 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7421412 | 0.89 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7425188 | 0.85 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7424242 | 0.83 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7429183 | 0.83 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7424509 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7422978 | 0.82 | TAS2R14 (0.69) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7418318 | 0.82 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7423718 | 0.82 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |