Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 16/20 | 0.38 |
| ▸ | MMP9 | P14780 | 9/20 | 0.38 |
| ▸ | MMP13 | P45452 | 8/20 | 0.38 |
| ▸ | MMP1 | P03956 | 7/20 | 0.37 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413415 | 0.87 | MAPT (0.39) | HDAC1ADAM17MMP9MMP13MMP1 | |
| SCHEMBL7412717 | 0.85 | ADAM17 (0.56) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL7413633 | 0.85 | ADAM17 (0.56) | HDAC3HDAC1ADAM17MMP9MMP13 | |
| SCHEMBL6789274 | 0.82 | MAPT (0.44) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL3948420 | 0.81 | ADAM17 (0.47) | HDAC1ADAM17MMP9MMP13MMP1 | |
| SCHEMBL7462047 | 0.80 | ADAM17 (0.40) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL3939291 | 0.80 | ADAM17 (0.47) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL3949079 | 0.80 | ADAM17 (0.50) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL3947427 | 0.79 | ADAM17 (0.41) | HDAC1ADAM17MMP9MMP13MMP1 | |
| SCHEMBL3938780 | 0.78 | ADAM17 (0.56) | ADAM17MMP9MMP13MMP1ADAM10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147080-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044713-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID COMPOUNDS AS TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |