Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 12/20 | 0.41 |
| ▸ | MMP9 | P14780 | 7/20 | 0.41 |
| ▸ | MMP13 | P45452 | 6/20 | 0.41 |
| ▸ | MMP1 | P03956 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413415 | 0.95 | MAPT (0.39) | MAPTL3MBTL1ALDH1A1HPGDMEN1 | |
| SCHEMBL7416157 | 0.82 | HDAC3 (0.38) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL3942478 | 0.81 | ADAM17 (0.51) | ALDH1A1ADAM17MMP9MMP13MMP1 | |
| SCHEMBL3939291 | 0.81 | ADAM17 (0.47) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL3939279 | 0.80 | ADAM17 (0.46) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL3942155 | 0.79 | ADAM17 (0.43) | HPGDADAM17MMP9MMP13MMP1 | |
| SCHEMBL6662677 | 0.79 | ADAM17 (0.48) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL6662679 | 0.79 | ADAM17 (0.48) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL3940968 | 0.78 | ADAM17 (0.53) | ADAM17MMP9MMP13MMP1ADAM10 | |
| SCHEMBL7414772 | 0.78 | ADAM17 (0.57) | MAPTL3MBTL1ALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825354-B2 | OSTEOPOROSIS; RHEUMATIC DISEASES | WYETH HOLDINGS CORPORATION | 2004-11-30 | — | — | US | disclosed |