Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.65 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.47 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.47 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.47 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL8562628 | 0.85 | KCNH2 (0.61) | KCNH2HDAC6KCNN3SMN1; SMN2 | |
| Water SCHEMBL8566156 | 0.85 | KCNH2 (0.61) | KCNH2HDAC6KCNN3SMN1; SMN2 | |
| SCHEMBL8560605 | 0.85 | KCNH2 (0.61) | KCNH2HDAC6KCNN3SMN1; SMN2 | |
| SCHEMBL9697190 | 0.85 | KCNH2 (0.66) | KCNH2HDAC6KCNN3TSHRSMN1; SMN2 | |
| SCHEMBL3748349 | 0.85 | KCNH2 (0.63) | KCNH2ACHEBCHESMN1; SMN2JAK1 | |
| SCHEMBL9698375 | 0.85 | KCNH2 (0.66) | KCNH2HDAC6KCNN3TSHRSMN1; SMN2 | |
| SCHEMBL9538786 | 0.85 | KCNH2 (0.65) | KCNH2ACHETSHR | |
| Hydrochloric Acid SCHEMBL8564807 | 0.84 | KCNH2 (0.60) | KCNH2HDAC6KCNN3SMN1; SMN2 | |
| SCHEMBL28406604 | 0.83 | HDAC6 (0.57) | KCNH2HDAC6KCNN3SMN1; SMN2 | |
| SCHEMBL11266594 | 0.83 | KCNH2 (0.80) | KCNH2TSHRSMN1; SMN2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196410-A1 | RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001000615-A1 | RESPIRATORY SYNCYTIAL VIRUS REPLICATION INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-01-04 | — | — | WO | disclosed |