Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11266594 | 0.85 | KCNH2 (0.80) | KCNH2TSHRCHRNA7SMN1; SMN2JAK1 | |
| SCHEMBL7416758 | 0.85 | KCNH2 (0.65) | KCNH2TSHRHDAC6KCNN3SMN1; SMN2 | |
| Water SCHEMBL8562628 | 0.83 | KCNH2 (0.61) | KCNH2HDAC6KCNN3SMN1; SMN2 | |
| Water SCHEMBL8566156 | 0.83 | KCNH2 (0.61) | KCNH2HDAC6KCNN3SMN1; SMN2 | |
| SCHEMBL8560605 | 0.83 | KCNH2 (0.61) | KCNH2HDAC6KCNN3SMN1; SMN2 | |
| SCHEMBL9697190 | 0.82 | KCNH2 (0.66) | KCNH2TSHRHDAC6KCNN3SMN1; SMN2 | |
| SCHEMBL3748349 | 0.82 | KCNH2 (0.63) | KCNH2SMN1; SMN2JAK1KMT2AGRIN2B | |
| SCHEMBL9538786 | 0.82 | KCNH2 (0.65) | KCNH2TSHRCHRNA7 | |
| Hydrochloric Acid SCHEMBL8564807 | 0.82 | KCNH2 (0.60) | KCNH2HDAC6KCNN3SMN1; SMN2 | |
| SCHEMBL1151915 | 0.82 | KCNH2 (0.59) | KCNH2TSHRCHRNA7HDAC6KCNN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE33833-E | Intermediates for antihistamines, antiserotonine agents | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-25 | — | — | US | disclosed |
| US-4820822-A | ANTIHISTAMINE, ANTISEROTONINE AGENTS | JANSSEN PHARMACEUTICA (BE) | 1989-04-11 | — | — | US | disclosed |
| EP-0145037-B1 | N-(BICYCLIC HETEROCYCLYL)-4-PIPERIDINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-18 | — | — | EP | disclosed |
| US-4760074-A | Novel-N-(bicyclic heterocyclyl)-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-07-26 | — | — | US | disclosed |
| EP-0099139-B1 | NOVEL N-(BICYCLIC HETEROCYCLYL)-4-PIPERIDINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-02-11 | — | — | EP | disclosed |
| US-4634704-A | HISTAMINE AND SEROTONINE ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-01-06 | — | — | US | disclosed |
| US-4556660-A | ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-12-03 | — | — | US | disclosed |
| EP-0145037-A2 | N-(bicyclic heterocyclyl)-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-06-19 | — | — | EP | disclosed |
| EP-0099139-A2 | Novel N-(bicyclic heterocyclyl)-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-01-25 | — | — | EP | disclosed |