Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.45 |
| ▸ | GAK | O14976 | 2/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | ADK | P55263 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 3/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 3/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6799283 | 0.82 | NT5E (0.47) | NT5EGAKKDRFYN | |
| SCHEMBL6804619 | 0.79 | NT5E (0.69) | NT5EGAKCDK8KDRHPGD | |
| SCHEMBL6797821 | 0.78 | NT5E (0.47) | NT5EGAKKDR | |
| SCHEMBL6803619 | 0.76 | GABRG2 (0.52) | NT5EGAKCDK8KDR | |
| SCHEMBL6804409 | 0.76 | NT5E (0.44) | NT5EGAKCDK8KDRHPGD | |
| SCHEMBL6796978 | 0.75 | NT5E (0.45) | NT5EGAKCDK8KDRHPGD | |
| SCHEMBL6803865 | 0.74 | NT5E (0.42) | NT5EGAKCDK8KDRHPGD | |
| SCHEMBL6799281 | 0.73 | NT5E (0.43) | NT5EGAKKDRHPGD | |
| SCHEMBL6798778 | 0.73 | NT5E (0.45) | NT5EGAKKDRHPGD | |
| SCHEMBL6807826 | 0.72 | NT5E (0.44) | NT5EGAKCDK8KDRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214319-A1 | IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | Merck Sharp & Dohme Limited (GB) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018000-A1 | IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-03-15 | — | — | WO | disclosed |