SCHEMBL7417301

SCHEMBL7417301

O=C(NC(=NCCCNc1nc2ccccc2cc1Cc1ccc(Br)cc1)NCCCc1c[nH]cn1)c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HRH2 P25021 3/20 0.33
HSP90AA1 P07900 1/20 0.31
POLB P06746 1/20 0.31
BRD4 O60885 1/20 0.30
HDAC6 Q9UBN7 1/20 0.30
DRD2 P14416 1/20 0.30
DRD3 P35462 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7533948 0.81 HRH2 (0.34) HRH2HSP90AA1
SCHEMBL11080965 0.77 HRH2 (0.43) HRH2POLB
SCHEMBL11080973 0.77 HRH2 (0.43) HRH2POLB
SCHEMBL9866822 0.77 HRH2 (0.52) HRH2
SCHEMBL9867162 0.77 HRH2 (0.52) HRH2
SCHEMBL9866817 0.77 HRH2 (0.52) HRH2
SCHEMBL9867137 0.76 HRH2 (0.49) HRH2
SCHEMBL9865344 0.76 HRH2 (0.49) HRH2
SCHEMBL11080978 0.76 HRH2 (0.47) HRH2HDAC6
SCHEMBL9865348 0.74 HRH2 (0.53) HRH2HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1019050-B1 USE OF SOMATOSTATIN AGONISTS AND ANTAGONISTS FOR TREATING DISEASES RELATED TO THE EYE NOVO NORDISK AS (DK) 2002-03-20 EP claimed
US-6159941-A Use of somatostatin agonists and antagonists for treating diseases related to the eye NOVO NORDISK A/S (DK) 2000-12-12 US claimed
US-6127343-A SELECTIVE, COMPETITIVE SOMATOSTATIN RECEPTOR LIGANDS OF NONPEPTIDE ORIGIN, FOR MEDIATING THE BIOLOGICAL EFFECT OF SOMATOSTATIN AGONISTS OR ANTAGONIST NOVO NORDISK A/S (DK) 2000-10-03 US claimed
EP-1019050-A1 USE OF SOMATOSTATIN AGONISTS AND ANTAGONISTS FOR TREATING DISEASES RELATED TO THE EYE NOVO NORDISK A/S (DK) 2000-07-19 EP claimed
EP-0912551-A1 SOMATOSTATIN AGONISTS AND ANTAGONISTS NOVO NORDISK A/S (DK) 1999-05-06 EP claimed
WO-1998058646-A1 USE OF SOMATOSTATIN AGONISTS AND ANTAGONISTS FOR TREATING DISEASES RELATED TO THE EYE NOVO NORDISK A/S (DK) 1998-12-30 WO claimed
WO-1997043278-A1 SOMATOSTATIN AGONISTS AND ANTAGONISTS NOVO NORDISK A/S (DK) 1997-11-20 WO claimed