Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Orbofiban. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 18/20 | 0.95 |
| ▸ | ITGA2B | P08514 | 18/20 | 0.95 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 9/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 9/20 | 0.47 |
| ▸ | F10 | P00742 | 5/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.40 |
| ▸ | FPR1 | P21462 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orbofiban SCHEMBL871101 | 0.99 | ITGB3 (0.93) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| Orbofiban SCHEMBL7854981 | 0.97 | ITGB3 (1.00) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| Orbofiban SCHEMBL7415135 | 0.97 | ITGB3 (1.00) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| Orbofiban SCHEMBL7411884 | 0.93 | ITGB3 (0.88) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7444902 | 0.90 | ITGB3 (0.86) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| Acetic Acid SCHEMBL7418342 | 0.89 | ITGB3 (0.75) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7451885 | 0.89 | ITGB3 (0.84) | ITGB3ITGA2BFPR1FPR2 | |
| Acetic Acid SCHEMBL8109437 | 0.89 | ITGB3 (0.75) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7448694 | 0.89 | ITGB3 (0.83) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7446820 | 0.89 | ITGB3 (0.80) | ITGB3ITGA2BPRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049453-A2 | METHODS OF TREATING MUSCULOSKELETAL INJURIES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2025-03-06 | — | — | WO | disclosed |
| EP-3728570-B1 | GLYCOENGINEERING | MASSACHUSETTS GEN HOSPITAL (US) | 2025-02-12 | — | — | EP | disclosed |
| US-20240174988-A1 | GLYCOENGINEERING | THE GENERAL HOSPITAL CORPORATION | 2024-05-30 | — | — | US | disclosed |
| US-11674125-B2 | Glycoengineering | THE GENERAL HOSPITAL CORPORATION (US) | 2023-06-13 | — | — | US | disclosed |
| EP-1068183-A2 | PROCESS FOR THE PREPARATION OF A 2-OXOPYRROLIDINE COMPOUND | G.D. SEARLE & CO. (US) | 2001-01-17 | — | — | EP | disclosed |
| EP-0796245-B1 | PROCESS FOR THE PREPARATION OF AMIDINO PHENYL PYRROLIDINE BETA-ALANINE UREA ANALOGS | SEARLE & CO (US) | 2000-07-26 | — | — | EP | disclosed |
| US-6025358-A | Double prodrugs of potent GP IIb/IIIa antagonists | G. D. SEARLE & CO. (US) | 2000-02-15 | — | — | US | disclosed |
| WO-1999064397-A1 | DOUBLE PRODRUGS OF POTENT GPIIb/IIIa ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-12-16 | — | — | WO | disclosed |
| US-5986107-A | Process for the preparation of a 2-oxopyrrolidine compound | G. D. SEARLE & CO. (US) | 1999-11-16 | — | — | US | disclosed |
| WO-1999051573-A2 | PROCESS FOR THE PREPARATION OF A 2-OXOPYRROLIDINE COMPOUND | G.D. SEARLE & CO. (US) | 1999-10-14 | — | — | WO | disclosed |
| US-5659063-A | AMINE-BLOCKED METHIONINE ANALOG CYCLIZABLE TO A LACTAM IN NONVOLATILE OR NONTOXIC REAGENTS; ANTITHROMBOTIC AGENTS | G. D. SEARLE & CO. (US) | 1997-08-19 | — | — | US | disclosed |
| US-5610296-A | CHEMICAL INTERMEDIATES OF ANTITHROMBOTICS | G. D. SEARLE & CO. (US) | 1997-03-11 | — | — | US | disclosed |
| US-5576447-A | Process for the preparation of amidino phenyl pyrrolidine β-alanine urea analogs | G. D. SEARLE & CO. (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1996017827-A1 | PROCESS FOR THE PREPARATION OF AMIDINO PHENYL PYRROLIDINE β-ALANINE UREA ANALOGS | G.D. SEARLE & CO. (US) | 1996-06-13 | — | — | WO | disclosed |
| US-5484946-A | CYCLIZATION AND DEHYDRATION A METHIONINE DERIVATIVE | G. D. SEARLE & CO. (US) | 1996-01-16 | — | — | US | disclosed |