Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 8/20 | 0.36 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.33 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10880207 | 1.00 | POLB (0.40) | POLBMAPTACEMMEITGB1 | |
| SCHEMBL10361083 | 0.77 | ITGB1 (0.39) | POLBMAPTACEITGB1ITGA5 | |
| SCHEMBL6942583 | 0.77 | ITGB1 (0.39) | POLBMAPTACEITGB1ITGA5 | |
| SCHEMBL10362062 | 0.77 | ITGB1 (0.39) | POLBMAPTACEITGB1ITGA5 | |
| SCHEMBL4698531 | 0.76 | ACE (0.33) | POLBMAPTACEITGB1ITGA5 | |
| SCHEMBL760162 | 0.71 | POLB (0.39) | POLBMAPTITGB1ITGA5ITGB3 | |
| SCHEMBL760161 | 0.71 | POLB (0.39) | POLBMAPTITGB1ITGA5ITGB3 | |
| SCHEMBL2540013 | 0.71 | POLB (0.39) | POLBMAPTITGB1ITGA5ITGB3 | |
| SCHEMBL30229890 | 0.71 | POLB (0.39) | POLBMAPTITGB1ITGA5ITGB3 | |
| SCHEMBL31742444 | 0.70 | ACE (0.48) | POLBMAPTACERAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0204440-A1 | Azetidine derivatives production | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1986-12-10 | — | — | EP | claimed |
| EP-1089973-A4 | AMIDINO AND GUANIDINO AZETIDINONE TRYPTASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-1089973-A1 | AMIDINO AND GUANIDINO AZETIDINONE TRYPTASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067215-A1 | AMIDINO AND GUANIDINO AZETIDINONE TRYPTASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-29 | — | — | WO | disclosed |
| EP-0204440-A1 | Azetidine derivatives production | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1986-12-10 | — | — | EP | disclosed |