Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.60 |
| ▸ | ITK | Q08881 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.40 |
| ▸ | PGR | P06401 | 3/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5350689 | 0.84 | MTNR1A (0.60) | MTNR1AMTNR1BITKALOX5PTGS2 | |
| SCHEMBL5359029 | 0.84 | MTNR1A (0.60) | MTNR1AMTNR1BITKALOX5PTGS2 | |
| SCHEMBL7808561 | 0.83 | MTNR1A (0.61) | MTNR1AMTNR1BITKHRH4FLT3 | |
| SCHEMBL19921264 | 0.80 | MTNR1A (0.60) | MTNR1AMTNR1BITKHRH4FLT3 | |
| SCHEMBL7412802 | 0.76 | MTNR1A (0.48) | MTNR1AMTNR1BPARP1 | |
| SCHEMBL9540950 | 0.75 | PARP1 (0.61) | MTNR1AMTNR1BAPLNRGPR84PARP1 | |
| SCHEMBL11199718 | 0.75 | MTNR1A (0.62) | MTNR1AMTNR1BITKHRH4FLT3 | |
| SCHEMBL27285942 | 0.74 | KDM5A (0.49) | MTNR1AMTNR1BPARP1 | |
| SCHEMBL6992510 | 0.72 | MTNR1A (0.50) | MTNR1AMTNR1BITKHRH4FLT3 | |
| SCHEMBL476670 | 0.72 | ITK (0.48) | MTNR1AMTNR1BITKHRH4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |