Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 9/20 | 0.42 |
| ▸ | CTSL | P07711 | 10/20 | 0.41 |
| ▸ | LONP1 | P36776 | 3/20 | 0.41 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.41 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.41 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.41 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.41 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.41 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.41 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.41 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.41 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.41 |
| ▸ | PSMB6 | P28072 | 2/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.41 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.41 |
| ▸ | PSMB3 | P49720 | 2/20 | 0.41 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.41 |
| ▸ | PSMA6 | P60900 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7536451 | 0.90 | LONP1 (0.41) | CTSSCTSLLONP1PSMB11PSMA7 | |
| SCHEMBL7419026 | 0.88 | LONP1 (0.42) | CTSSCTSLLONP1PSMB11PSMA7 | |
| SCHEMBL5364883 | 0.80 | CTSS (0.54) | CTSSCTSLLONP1PSMB11PSMA7 | |
| SCHEMBL5364891 | 0.80 | CTSS (0.54) | CTSSCTSLLONP1PSMB11PSMA7 | |
| SCHEMBL7004000 | 0.75 | CTSS (0.50) | CTSSCTSLCTSBCTSK | |
| SCHEMBL7007584 | 0.74 | CTSL (0.51) | CTSSCTSLCTSBCTSK | |
| SCHEMBL7010006 | 0.73 | CTSS (0.49) | CTSSCTSLCTSBCTSKCPB2 | |
| SCHEMBL7413842 | 0.73 | CTSS (0.40) | CTSSCTSLCTSBCTSKCPB2 | |
| SCHEMBL5364816 | 0.72 | CTSS (0.51) | CTSSCTSLLONP1PSMB11PSMA7 | |
| SCHEMBL5364826 | 0.72 | CTSS (0.51) | CTSSCTSLLONP1PSMB11PSMA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218372-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001019816-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | disclosed |