Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.62 |
| ▸ | PDE4A | P27815 | 7/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.52 |
| ▸ | TPH1 | P17752 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088472 | 0.90 | PDE4B (0.65) | PDE4BPDE4DPDE4APDE4CRECQL | |
| SCHEMBL6816260 | 0.88 | KMT2A (0.58) | PDE4BPDE4DPDE4APDE4CRECQL | |
| SCHEMBL7359769 | 0.86 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4CRECQL | |
| SCHEMBL7026447 | 0.85 | PDE4B (0.58) | PDE4BPDE4DPDE4APDE4CRECQL | |
| SCHEMBL7477238 | 0.83 | RECQL (0.62) | PDE4BPDE4DPDE4APDE4CRECQL | |
| SCHEMBL7362499 | 0.82 | ALDH1A1 (0.61) | PDE4BPDE4DPDE4APDE4CRECQL | |
| SCHEMBL7091205 | 0.81 | PDE4B (0.57) | PDE4BPDE4DPDE4APDE4CRECQL | |
| SCHEMBL9274706 | 0.81 | PDE4B (0.51) | PDE4BPDE4DPDE4APDE4CRECQL | |
| SCHEMBL9272637 | 0.81 | PDE4B (0.65) | PDE4BPDE4DPDE4APDE4CEPHX2 | |
| SCHEMBL8571660 | 0.81 | KMT2A (0.61) | PDE4BPDE4DPDE4APDE4CRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993015044-A1 | N-BENZYLOXAMIC ACID, OXAMATE, AND OXAMIDE DERIVATIVES AND THEIR USE AS TNF AND PDE IV INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-08-05 | — | — | WO | claimed |
| EP-2193808-A1 | Synergistic combination | Nycomed GmbH (DE) | 2010-06-09 | — | — | EP | disclosed |
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |
| WO-1993015044-A1 | N-BENZYLOXAMIC ACID, OXAMATE, AND OXAMIDE DERIVATIVES AND THEIR USE AS TNF AND PDE IV INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-08-05 | — | — | WO | disclosed |