Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417012 | 0.79 | KMT2A (0.49) | KMT2AMEN1ALDH1A1NPSR1KDM4E | |
| SCHEMBL1171415 | 0.75 | KMT2A (0.69) | KMT2AMEN1ALDH1A1NPSR1KDM4E | |
| SCHEMBL1171410 | 0.75 | KMT2A (0.69) | KMT2AMEN1ALDH1A1NPSR1KDM4E | |
| SCHEMBL30611213 | 0.74 | KMT2A (0.68) | KMT2AMEN1ALDH1A1NPSR1KDM4E | |
| SCHEMBL29045884 | 0.74 | KMT2A (0.68) | KMT2AMEN1ALDH1A1NPSR1KDM4E | |
| SCHEMBL29045872 | 0.74 | KMT2A (0.68) | KMT2AMEN1ALDH1A1NPSR1KDM4E | |
| SCHEMBL7273959 | 0.73 | ELANE (0.70) | KMT2AMEN1ALDH1A1HTT | |
| SCHEMBL7283320 | 0.71 | ELANE (0.69) | — | |
| SCHEMBL9173331 | 0.70 | KMT2A (0.52) | KMT2AMEN1ALDH1A1NPSR1KDM4E | |
| SCHEMBL23961083 | 0.70 | ALDH1A1 (0.67) | KMT2AMEN1ALDH1A1NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532366-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-07-02 | — | — | US | disclosed |
| EP-0649432-A1 | FLUORINE COMPRISING DIPEPTIDES AS INHIBITORS AGAINST HUMAN LEUCOCYTE ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1995-04-26 | — | — | EP | disclosed |
| WO-1994001455-A1 | FLUORINE COMPRISING DIPEPTIDES AS INHIBITORS AGAINST HUMAN LEUCOCYTE ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1994-01-20 | — | — | WO | disclosed |