Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.45 |
| ▸ | CCND1 | P24385 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410811 | 0.89 | ALDH1A1 (0.51) | DYRK1AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL14347582 | 0.87 | KDM4E (0.51) | DYRK1AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4782075 | 0.79 | KDM4E (0.59) | DYRK1AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1622459 | 0.78 | KDM4E (0.54) | DYRK1AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL27951831 | 0.78 | METAP2 (0.41) | DYRK1AKDM4EALDH1A1CDK4CCND1 | |
| SCHEMBL12348055 | 0.76 | DYRK1A (0.55) | DYRK1AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL14374836 | 0.75 | KDM4E (0.51) | DYRK1AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13729799 | 0.74 | MEN1 (0.61) | DYRK1AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1772236 | 0.74 | KDM4E (0.65) | KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL26086462 | 0.73 | KDM4E (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4631283-A | RENAL VASODILATORS, CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-12-23 | — | — | US | disclosed |
| US-4490374-A | CARDIOVASCULAR AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0107398-A1 | Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids | ORTHO PHARMACEUTICAL CORPORATION (US) | 1984-05-02 | — | — | EP | disclosed |