Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 4/20 | 0.39 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 2/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28816482 | 0.75 | SMN1; SMN2 (0.54) | TDP2HTR2AHTR2CSMN1; SMN2 | |
| SCHEMBL4992270 | 0.74 | PARP11 (0.42) | HTR2ASMN1; SMN2 | |
| SCHEMBL10857007 | 0.74 | SMN1; SMN2 (0.47) | TDP2KDM1ASMN1; SMN2KMT2A | |
| SCHEMBL19925576 | 0.72 | KDM1A (0.52) | KDM1AKDM1BHTR2AHTR2CACHE | |
| Hydrochloric Acid SCHEMBL21408621 | 0.71 | KDM1A (0.50) | KDM1AKDM1BHTR2AHTR2CACHE | |
| Hydrochloric Acid SCHEMBL19925562 | 0.71 | KDM1A (0.50) | KDM1AKDM1BHTR2AHTR2CACHE | |
| SCHEMBL38658784 | 0.70 | ACHE (0.39) | TDP2HTR2AHTR2CACHEPARP1 | |
| SCHEMBL5897678 | 0.67 | PARP10 (0.39) | TDP2KDM1AKDM1BHTR2AHTR2C | |
| SCHEMBL30648196 | 0.66 | AHR (0.61) | TDP2SMN1; SMN2MEN1NPC1KMT2A | |
| SCHEMBL260027 | 0.66 | AHR (0.61) | TDP2SMN1; SMN2MEN1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951466-A2 | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | Elan Pharmaceuticals, Inc. (US) | 1999-10-27 | — | — | EP | disclosed |
| WO-1998028268-A2 | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS AS β-AMYLOID PEPTIDE RELEASE INHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 1998-07-02 | — | — | WO | disclosed |