Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ANPEP | P15144 | 4/20 | 0.53 |
| ▸ | HTR2A | P28223 | 9/20 | 0.50 |
| ▸ | HRH1 | P35367 | 5/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CASP9 | P55211 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2532588 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2ANPEPHTR2AHRH1HTR2C | |
| SCHEMBL7821415 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2ANPEPHTR2AHRH1HTR2C | |
| SCHEMBL4992270 | 0.76 | PARP11 (0.42) | SMN1; SMN2ANPEPHTR2A | |
| SCHEMBL21035184 | 0.76 | SMN1; SMN2 (0.76) | SMN1; SMN2ANPEPHTR2AHRH1HTR2C | |
| SCHEMBL21035183 | 0.76 | SMN1; SMN2 (0.76) | SMN1; SMN2ANPEPHTR2AHRH1HTR2C | |
| SCHEMBL31350550 | 0.76 | SMN1; SMN2 (0.76) | SMN1; SMN2ANPEPHTR2AHRH1HTR2C | |
| SCHEMBL11439131 | 0.76 | SMN1; SMN2 (0.76) | SMN1; SMN2ANPEPHTR2AHRH1HTR2C | |
| SCHEMBL7418174 | 0.75 | TDP2 (0.39) | SMN1; SMN2HTR2AHTR2CTDP2 | |
| SCHEMBL19953614 | 0.75 | SMN1; SMN2 (0.49) | SMN1; SMN2ANPEPHTR2AHRH1HTR2C | |
| SCHEMBL8327735 | 0.74 | ANPEP (0.42) | SMN1; SMN2ANPEPHTR2AHRH1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103524412-B | Isoquinolone derivative and synthetic method thereof | GUANGDONG HOSPITAL TRADITIONAL CHINESE MEDICINE | 2015-02-18 | — | — | CN | claimed |
| CN-103524412-B | Isoquinolone derivative and synthetic method thereof | GUANGDONG HOSPITAL TRADITIONAL CHINESE MEDICINE | 2015-02-18 | — | — | CN | disclosed |