Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.69 |
| ▸ | TAS2R14 | Q9NYV8 | 10/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | CNR1 | P21554 | 1/20 | 0.59 |
| ▸ | CNR2 | P34972 | 1/20 | 0.59 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | PTGES | O14684 | 1/20 | 0.52 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.52 |
| ▸ | EP300 | Q09472 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417394 | 0.92 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7423414 | 0.90 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7422978 | 0.88 | TAS2R14 (0.69) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7423502 | 0.87 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7422229 | 0.85 | TAS2R14 (0.89) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7416861 | 0.84 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7424851 | 0.84 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7419350 | 0.84 | PDE4D (0.67) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7422201 | 0.84 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7421289 | 0.84 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DTAS2R14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |