Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | BCL9 | O00512 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14296886 | 0.83 | HTR2A (0.50) | HTR2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL18195673 | 0.82 | HTR2A (0.46) | HTR2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7370457 | 0.82 | HTR2A (0.46) | HTR2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7418355 | 0.81 | HTR2A (0.57) | HTR2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1714950 | 0.80 | HTR2A (0.70) | HTR2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4644851 | 0.80 | HTR2A (0.56) | HTR2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL29592309 | 0.80 | HTR2A (0.62) | HTR2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30232724 | 0.79 | BCL9 (0.51) | HTR2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL22033527 | 0.79 | HTR2A (0.50) | HTR2ASMN1; SMN2ALDH1A1BCL9CTNNB1 | |
| SCHEMBL389680 | 0.78 | ALDH1A1 (0.52) | HTR2ASMN1; SMN2ALDH1A1BCL9CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5907068-A | TRIFLUOROMETHYLSUBSTITUTED COMPOUND INCLUDED IN PEPTIDES | ZENECA INC. (US) | 1999-05-25 | — | — | US | disclosed |
| US-5726158-A | INHIBITORS OF HUMAN LEUKOCYTE ELASTASE USEFUL IN TREATING TISSUE DEGENERATIVE DISEASES; TRIFLUOROMETHYL KETONE SUBSTITUTED DI-, TRI-, AND TETRA-PEPTIDE DERIVATIVES | ZENECA INC. (US) | 1998-03-10 | — | — | US | disclosed |
| US-5414132-A | Peptide intermediates | ZENECA INC. (US) | 1995-05-09 | — | — | US | disclosed |
| US-5194588-A | Inhibitors of human leukocyte elastase, di-, tri- and tetra-peptides | ICI AMERICAS INC. (US) | 1993-03-16 | — | — | US | disclosed |
| EP-0189305-B1 | PEPTIDE DERIVATIVES | ICI AMERICAS INC. (US) | 1992-07-29 | — | — | EP | disclosed |
| US-5055450-A | Di-, tri- and tetrapeptides as inhibitors of human leukocyte elastase | ICI AMERICAS INC. (US) | 1991-10-08 | — | — | US | disclosed |
| EP-0189305-A2 | Peptide derivatives | ICI AMERICAS INC. (US) | 1986-07-30 | — | — | EP | disclosed |