Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413420 | 0.88 | NR1H2 (0.39) | KDM4EALDH1A1HPGDNR1H2ITGB3 | |
| SCHEMBL7419083 | 0.73 | NR1H2 (0.39) | KDM4EALDH1A1HPGDNR1H2HSD17B3 | |
| SCHEMBL30561539 | 0.73 | MEN1 (0.54) | CRBNDRD2 | |
| SCHEMBL2386047 | 0.73 | MEN1 (0.54) | CRBNDRD2 | |
| SCHEMBL7420931 | 0.69 | ACHE (0.39) | ALDH1A1DRD2MAPTCASP1CASP7 | |
| Hydrochloric Acid SCHEMBL7307645 | 0.69 | TNF (0.40) | KDM4EALDH1A1HPGDNR1H2CASP1 | |
| SCHEMBL2616858 | 0.67 | CA12 (0.46) | KDM4EALDH1A1HPGDNR1H2TYMS | |
| SCHEMBL28159868 | 0.64 | KDM4E (0.56) | KDM4EALDH1A1HPGDITGB3ITGA2B | |
| SCHEMBL30367367 | 0.64 | HRH3 (0.56) | — | |
| SCHEMBL19462370 | 0.64 | HRH3 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5602145-A | Bicyclic fibrinogen antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-11 | — | — | US | disclosed |
| EP-0702671-A4 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1996-06-19 | — | — | EP | disclosed |
| EP-0702671-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-03-27 | — | — | EP | disclosed |
| WO-1994029273-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-22 | — | — | WO | disclosed |