Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31681723 | 0.89 | CA2 (0.48) | PDE4ATTRNPC1POLBRAB9A | |
| SCHEMBL5026284 | 0.89 | CA2 (0.48) | PDE4ATTRNPC1POLBRAB9A | |
| SCHEMBL16955648 | 0.86 | HTT (0.49) | PDE4APDE4BPDE4CPDE4DCYP4F2 | |
| SCHEMBL7869796 | 0.86 | DRD1 (0.46) | PDE4APDE4BPDE4CPDE4DCYP4F2 | |
| SCHEMBL5761057 | 0.85 | PDE4D (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL22981677 | 0.85 | CYP4F2 (0.56) | PDE4ACYP4F2CYP4A11 | |
| SCHEMBL16953563 | 0.85 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DCYP4F2 | |
| SCHEMBL30640919 | 0.85 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DCYP4F2 | |
| SCHEMBL3125593 | 0.85 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16958146 | 0.85 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DCYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636026-B1 | COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES AND INHIBITING PRODUCTION OF TUMOR NECROSIS FACTOR | SMITHKLINE BEECHAM CORP (US) | 2001-12-05 | — | — | EP | disclosed |
| EP-0636025-B1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORP (US) | 2001-07-18 | — | — | EP | disclosed |
| US-5811455-A | Compounds useful for treating allergic or inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1998-09-22 | — | — | US | disclosed |
| US-5631286-A | Compounds useful for treating allergic or inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-20 | — | — | US | disclosed |
| US-5605923-A | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-25 | — | — | US | disclosed |
| US-5449686-A | Compounds useful for treating allergic or inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1995-09-12 | — | — | US | disclosed |
| EP-0636026-A4 | — | — | 1995-02-22 | — | — | EP | disclosed |
| EP-0636025-A4 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES. | — | 1995-02-22 | — | — | EP | disclosed |
| EP-0636026-A1 | COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES AND INHIBITING PRODUCTION OF TUMOR NECROSIS FACTOR | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-01 | — | — | EP | disclosed |
| EP-0636025-A1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993019751-A1 | COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES AND INHIBITING PRODUCTION OF TUMOR NECROSIS FACTOR | SMITHKLINE BEECHAM CORPORATION (US) | 1993-10-14 | — | — | WO | disclosed |
| WO-1993019750-A1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-10-14 | — | — | WO | disclosed |