Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.35 |
| ▸ | KLK7 | P49862 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9056470 | 1.00 | EPHX2 (0.35) | EPHX2KLK7HPGDTSHRSMYD3 | |
| SCHEMBL7366114 | 0.87 | TSHR (0.35) | EPHX2KLK7HPGDTSHRALDH1A1 | |
| SCHEMBL7366111 | 0.87 | TSHR (0.35) | EPHX2KLK7HPGDTSHRALDH1A1 | |
| SCHEMBL7366425 | 0.81 | TSHR (0.35) | EPHX2KLK7TSHR | |
| SCHEMBL7366423 | 0.81 | TSHR (0.35) | EPHX2KLK7TSHR | |
| SCHEMBL7368625 | 0.79 | EPHX2 (0.31) | EPHX2SMYD3 | |
| SCHEMBL2265394 | 0.78 | KDM4E (0.35) | MEN1KMT2A | |
| SCHEMBL8415958 | 0.77 | GAA (0.40) | SMYD3ALDH1A1MEN1KMT2A | |
| SCHEMBL8415956 | 0.77 | GAA (0.40) | SMYD3ALDH1A1MEN1KMT2A | |
| SCHEMBL698490 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777667-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | Dr. Karl Thomae GmbH (DE) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996005194-A1 | CYCLIC BENZAZEPINE UREA DERIVATIVES WITH AGGREGATION-INHIBITING EFFECT | DR. KARL THOMAE GMBH (DE) | 1996-02-22 | — | — | WO | disclosed |
| WO-1996004271-A1 | CONDENSED AZEPINE DERIVATIVES, DRUGS CONTAINING THESE COMPOUNDS AND METHODS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-02-15 | — | — | WO | disclosed |