Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.57 |
| ▸ | PDE4A | P27815 | 13/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.57 |
| ▸ | BACE1 | P56817 | 5/20 | 0.31 |
| ▸ | CTSD | P07339 | 2/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31574681 | 0.83 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6357472 | 0.83 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7866744 | 0.82 | PDE4B (0.46) | PDE4BPDE4APDE4CPDE4DBACE1 | |
| SCHEMBL15256620 | 0.78 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7416563 | 0.76 | SLC6A4 (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6546375 | 0.76 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7415768 | 0.76 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DBACE1 | |
| SCHEMBL7460382 | 0.73 | PDE4A (0.44) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7423821 | 0.73 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8532718 | 0.70 | SLC6A4 (0.47) | PDE4BPDE4APDE4CPDE4DBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636025-B1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORP (US) | 2001-07-18 | — | — | EP | claimed |
| EP-0636025-A4 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES. | — | 1995-02-22 | — | — | EP | claimed |
| EP-0636025-A1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-01 | — | — | EP | claimed |
| WO-1993019750-A1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-10-14 | — | — | WO | claimed |