Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.46 |
| ▸ | PDE4A | P27815 | 9/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31574681 | 0.88 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL6357472 | 0.88 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL7419178 | 0.82 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4DBACE1 | |
| SCHEMBL15256620 | 0.78 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4DHPGD | |
| SCHEMBL7869820 | 0.76 | PDE4A (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7866876 | 0.76 | SLC6A4 (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7864287 | 0.75 | PDE4B (0.75) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6351319 | 0.74 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL7866906 | 0.73 | CASP1 (0.39) | PDE4BPDE4APDE4CPDE4DHTT | |
| SCHEMBL6356495 | 0.72 | PDE4B (0.39) | PDE4BPDE4APDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636025-B1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORP (US) | 2001-07-18 | — | — | EP | claimed |