Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8574237 | 0.90 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14402617 | 0.90 | PDE4B (0.67) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6821602 | 0.89 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6129899 | 0.88 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6545870 | 0.86 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7321654 | 0.85 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6129896 | 0.85 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6545755 | 0.84 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30683833 | 0.84 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5495203 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5449687-A | 4-phenyl-1,2-cyclohexyl derivatives and anti-inflammatory compositions and methods thereof | SMITHKLINE BEECHAM CORPORATION (US) | 1995-09-12 | — | — | US | claimed |
| EP-0633771-A4 | COMPOUNDS. | — | 1995-02-22 | — | — | EP | claimed |
| EP-0633771-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-01-18 | — | — | EP | claimed |
| WO-1993019720-A2 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-10-14 | — | — | WO | claimed |
| US-5449687-A | 4-phenyl-1,2-cyclohexyl derivatives and anti-inflammatory compositions and methods thereof | SMITHKLINE BEECHAM CORPORATION (US) | 1995-09-12 | — | — | US | disclosed |
| EP-0633771-A4 | COMPOUNDS. | — | 1995-02-22 | — | — | EP | disclosed |
| EP-0633771-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-01-18 | — | — | EP | disclosed |
| WO-1993019720-A2 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-10-14 | — | — | WO | disclosed |