Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | PTGER1 | P34995 | 9/20 | 0.55 |
| ▸ | PDE4A | P27815 | 2/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.53 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.53 |
| ▸ | ACLY | P53396 | 1/20 | 0.53 |
| ▸ | EP300 | Q09472 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417394 | 0.79 | PDE4A (0.79) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7414327 | 0.79 | PDE4D (0.60) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7420825 | 0.78 | PDE4D (0.62) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7416808 | 0.77 | PDE4D (0.73) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7423502 | 0.75 | PDE4A (0.65) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7417326 | 0.75 | TAS2R14 (0.58) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7422201 | 0.74 | PDE4A (0.67) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7421289 | 0.74 | PDE4A (0.67) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7419350 | 0.74 | PDE4D (0.67) | SMN1; SMN2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6801637 | 0.74 | NR3C1 (0.63) | HIF1AEPAS1EP300LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |
| WO-1996036595-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |