Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 3/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6084502 | 0.99 | EPHX2 (0.55) | EPHX2KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL14503268 | 0.80 | EPHX2 (0.67) | EPHX2KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL6085448 | 0.77 | SMN1; SMN2 (0.54) | EPHX2KMT2AMEN1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL6084812 | 0.75 | P2RX7 (0.60) | EPHX2KMT2AMEN1ALDH1A1P2RX7 | |
| SCHEMBL6084644 | 0.74 | ALDH1A1 (0.52) | EPHX2KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL8704295 | 0.74 | GAA (0.55) | KMT2AMEN1ALDH1A1KDM4EGAA | |
| SCHEMBL29557428 | 0.74 | POLB (0.56) | KMT2AMEN1ALDH1A1KDM4EGAA | |
| SCHEMBL1816768 | 0.74 | POLB (0.56) | KMT2AMEN1ALDH1A1KDM4EGAA | |
| SCHEMBL5123431 | 0.74 | GAA (0.55) | KMT2AMEN1ALDH1A1KDM4EGAA | |
| Hydrochloric Acid SCHEMBL5774955 | 0.72 | GAA (0.53) | KMT2AMEN1ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037878-A2 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS FOR TREATING CENTRAL NERVOUS SYSTEM DISEASES | NPS PHARMACEUTICALS, INC. (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999026927-A2 | METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS FOR TREATING CENTRAL NERVOUS SYSTEM DISEASES | NPS PHARMACEUTICALS, INC. (US) | 1999-06-03 | — | — | WO | disclosed |