Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | USP14 | P54578 | 6/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418895 | 0.84 | ITGB3 (0.71) | ITGB3ITGA2B | |
| SCHEMBL7418903 | 0.83 | ITGB3 (0.51) | ITGB3ITGA2BPOLBKDM4ELMNA | |
| SCHEMBL7415603 | 0.83 | ITGB3 (0.72) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7420718 | 0.83 | ITGB3 (0.72) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7422053 | 0.80 | ITGB3 (0.40) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7418954 | 0.79 | ITGB3 (0.66) | ITGB3ITGA2BPOLBKDM4E | |
| SCHEMBL7418959 | 0.78 | ITGB3 (0.47) | ITGB3ITGA2BPOLBKDM4ELMNA | |
| SCHEMBL27368967 | 0.77 | ITGB3 (0.65) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7442381 | 0.76 | ITGB3 (0.62) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7417996 | 0.75 | HDAC1 (0.49) | HDAC1HDAC8HDAC6ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691953-B1 | 1-AMIDINOPHENYL-PYRROLIDONES/ PIPERIDINONES AS PLATELET AGGREGATION INHIBITORS | SEARLE & CO (US) | 2000-08-02 | — | — | EP | disclosed |
| CN-1124957-A | 1-amidinophenyl-pyrrolidones piperidinones azetinones as platelet aggregation inhibitors | SEARLE & CO (US) | 1996-06-19 | — | — | CN | disclosed |
| WO-1994022820-A1 | 1-AMIDINOPHENYL-PYRROLIDONES PIPERIDINONES AZETINONES AS PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1994-10-13 | — | — | WO | disclosed |