Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.72 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.72 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 6/20 | 0.45 |
| ▸ | FNTA | P49354 | 6/20 | 0.39 |
| ▸ | FNTB | P49356 | 6/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 5/20 | 0.39 |
| ▸ | FPR1 | P21462 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | USP14 | P54578 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415603 | 1.00 | ITGB3 (0.72) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL27368967 | 0.94 | ITGB3 (0.65) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7442381 | 0.93 | ITGB3 (0.62) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7449160 | 0.91 | ITGB3 (0.59) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7453824 | 0.91 | ITGB3 (0.60) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7446548 | 0.90 | ITGB3 (0.59) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7449777 | 0.90 | ITGB3 (0.59) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL7447587 | 0.90 | ITGB3 (0.59) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL8107898 | 0.88 | ITGB3 (0.56) | ITGB3ITGA2BHDAC1HDAC8HDAC6 | |
| SCHEMBL8102018 | 0.88 | ITGB3 (0.56) | ITGB3ITGA2BHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691953-B1 | 1-AMIDINOPHENYL-PYRROLIDONES/ PIPERIDINONES AS PLATELET AGGREGATION INHIBITORS | SEARLE & CO (US) | 2000-08-02 | — | — | EP | disclosed |
| CN-1124957-A | 1-amidinophenyl-pyrrolidones piperidinones azetinones as platelet aggregation inhibitors | SEARLE & CO (US) | 1996-06-19 | — | — | CN | disclosed |
| WO-1994022820-A1 | 1-AMIDINOPHENYL-PYRROLIDONES PIPERIDINONES AZETINONES AS PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1994-10-13 | — | — | WO | disclosed |