Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 7/20 | 0.40 |
| ▸ | HTR2C | P28335 | 4/20 | 0.40 |
| ▸ | HTR3A | P46098 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.39 |
| ▸ | HTR1D | P28221 | 4/20 | 0.39 |
| ▸ | HTR2B | P41595 | 4/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351451 | 0.78 | SLC6A2 (0.39) | HTR4HTR2CHTR3ACYP2D6CYP2C9 | |
| SCHEMBL7351448 | 0.71 | SLC6A2 (0.40) | HTR4HTR2CHTR3ACYP2D6CYP2C9 | |
| SCHEMBL7347480 | 0.71 | PRKAB2 (0.42) | HTR4HTR2CHTR3ACYP2D6CYP2C9 | |
| SCHEMBL7347476 | 0.71 | SLC6A2 (0.42) | HTR4HTR2CCYP2D6CYP2C9ADRA2C | |
| SCHEMBL7347472 | 0.71 | SLC6A2 (0.40) | HTR4CYP2D6CYP2C9SLC6A2SLC6A4 | |
| SCHEMBL8323267 | 0.67 | HTR4 (0.51) | HTR4HTR2CHTR3ACYP2D6CYP2C9 | |
| SCHEMBL7328039 | 0.67 | HTR4 (0.41) | HTR4HTR2CHTR3ACYP2D6CYP2C9 | |
| SCHEMBL8319379 | 0.66 | HTR4 (0.50) | HTR4HTR2CHTR3ACYP2D6CYP2C9 | |
| SCHEMBL8319897 | 0.66 | HTR4 (0.50) | HTR4HTR2CHTR3ACYP2D6CYP2C9 | |
| SCHEMBL8320836 | 0.66 | HTR4 (0.50) | HTR4HTR2CHTR3ACYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127379-A | TREATING IRRITABLE BOWEL SYNDROME, URINARY INCONTINENCE, ATRIAL ARRHYTHMIA OR STROKE | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-10-03 | — | — | US | disclosed |
| EP-0625149-A1 | BENZOPYRAN, BENZOTHIOPYRAN AND BENZOFURAN DERIVATIVES AS 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993016072-A1 | BENZOPYRAN, BENZOTHIOPYRAN AND BENZOFURAN DERIVATIVES AS 5-HT4 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-08-19 | — | — | WO | disclosed |