Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424333 | 0.82 | NOTUM (0.51) | NOTUMLMNAALDH1A1HPGDKDM4E | |
| SCHEMBL8528760 | 0.80 | NOTUM (0.65) | NOTUMLMNAALDH1A1HPGDKDM4E | |
| SCHEMBL9094480 | 0.77 | LMNA (0.66) | NOTUMLMNAALDH1A1HPGDKDM4E | |
| SCHEMBL7418643 | 0.74 | NOTUM (0.56) | NOTUMLMNAALDH1A1HPGDKDM4E | |
| SCHEMBL5009163 | 0.71 | NOTUM (1.00) | NOTUMALDH1A1HPGDKDM4ERECQL | |
| SCHEMBL29150848 | 0.71 | NOTUM (0.63) | NOTUMLMNAALDH1A1HPGDKDM4E | |
| SCHEMBL9088878 | 0.71 | NOTUM (0.66) | NOTUMLMNAALDH1A1HPGDKDM4E | |
| SCHEMBL423295 | 0.70 | NOTUM (1.00) | NOTUMALDH1A1HPGDKDM4ERECQL | |
| SCHEMBL6072422 | 0.70 | NOTUM (0.73) | NOTUMALDH1A1HPGDKDM4ERECQL | |
| SCHEMBL2848437 | 0.69 | LMNA (0.53) | NOTUMLMNAALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656003-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-06-07 | — | — | EP | disclosed |
| WO-1994004533-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-03-03 | — | — | WO | disclosed |