Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.66 |
| ▸ | NOTUM | Q6P988 | 7/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8528760 | 0.84 | NOTUM (0.65) | LMNANOTUMMAPTALDH1A1HPGD | |
| SCHEMBL14090157 | 0.78 | NOTUM (0.65) | LMNANOTUMGAAMAPTALDH1A1 | |
| SCHEMBL4796306 | 0.78 | HSD17B3 (0.63) | LMNANOTUMMAPTKDM4EPOLB | |
| SCHEMBL2205988 | 0.77 | NOTUM (1.00) | LMNANOTUMMAPTALDH1A1HPGD | |
| SCHEMBL7419829 | 0.77 | NOTUM (0.54) | LMNANOTUMGAAMAPTALDH1A1 | |
| SCHEMBL13020232 | 0.75 | NOTUM (0.61) | LMNANOTUMMAPTALDH1A1HPGD | |
| SCHEMBL5780390 | 0.75 | ALDH1A1 (0.70) | LMNANOTUMGAAMAPTALDH1A1 | |
| SCHEMBL423295 | 0.75 | NOTUM (1.00) | NOTUMMAPTALDH1A1HPGDKDM4E | |
| SCHEMBL6072422 | 0.75 | NOTUM (0.73) | NOTUMGAAMAPTALDH1A1HPGD | |
| SCHEMBL8527554 | 0.74 | NOTUM (0.62) | LMNANOTUMMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996011929-A1 | BIHETEROARYL-CARBONYL AND CARBOXAMIDE DERIVATIVES WITH 5HT 2C/2B ANTAGONISTS ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1996-04-25 | — | — | WO | disclosed |