Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351215 | 0.91 | ALDH1A1 (0.55) | ALDH1A1MAPTPOLBMAPK1PARP1 | |
| SCHEMBL7343583 | 0.87 | ALDH1A1 (0.46) | ALDH1A1MAPTPRMT5WDR77NSD2 | |
| SCHEMBL9590395 | 0.81 | MAPT (0.48) | ALDH1A1MAPTTHRBPRMT5WDR77 | |
| SCHEMBL9588570 | 0.81 | MAPT (0.44) | ALDH1A1MAPTPRMT5WDR77NSD2 | |
| SCHEMBL5467117 | 0.80 | ALDH1A1 (0.48) | ALDH1A1MAPTPRMT5WDR77NSD2 | |
| SCHEMBL29978611 | 0.79 | ALDH1A1 (0.52) | ALDH1A1MAPTPOLBNSD2PARP1 | |
| SCHEMBL303909 | 0.79 | ALDH1A1 (0.52) | ALDH1A1MAPTPOLBNSD2PARP1 | |
| SCHEMBL25720031 | 0.78 | GAA (0.52) | ALDH1A1MAPTPOLBPRMT5WDR77 | |
| SCHEMBL7341856 | 0.78 | ALDH1A1 (0.44) | ALDH1A1MAPTPRMT5WDR77NSD2 | |
| SCHEMBL7341253 | 0.78 | ALDH1A1 (0.58) | ALDH1A1MAPTPOLBMAPK1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5221742-A | PROCESS FOR THE PREPARATION OF 6-(3,4-DIHYDRO-3-OXO-1,4(2H)-BENZOXAZIN-7-YL)-2,3,4,5-TETRAHYDROPYRIDAZIN-3-ONES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-06-22 | — | — | US | disclosed |
| EP-0515668-A4 | OXO-TETRAHYDROPYRIDAZINYL-PYRAZOLO 4,3-B)-1,4-BENZOXAZINES | — | 1993-03-10 | — | — | EP | disclosed |
| EP-0515668-A1 | OXO-TETRAHYDROPYRIDAZINYL-PYRAZOLO 4,3-b]-1,4-BENZOXAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-12-02 | — | — | EP | disclosed |
| EP-0509845-A1 | (+) and (-) enantiomers of 5-aliphatic-6-(benzoxazinyl- or benzothiazinyl)-2,3,4,5-tetrahydropyridazin-3-ones | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-10-21 | — | — | EP | disclosed |
| WO-1992011265-A1 | OXO-TETRAHYDROPYRIDAZINYL-PYRAZOLO[4,3-b]-1,4-BENZOXAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-07-09 | — | — | WO | disclosed |
| US-5116837-A | 2,9-dihydro-(6 or 7)-(3-oxo-2,3,4,5-tetrahydropyridazinyl)-pyrazolo [4,3-B]-1,4-benzoxazines | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-05-26 | — | — | US | disclosed |