Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.64 |
| ▸ | HTR2A | P28223 | 4/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | DRD5 | P21918 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.54 |
| ▸ | HRH2 | P25021 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9478399 | 0.95 | LTA4H (0.61) | LTA4HHTR2ACHRM1MCHR1HRH3 | |
| SCHEMBL28285423 | 0.88 | SIGMAR1 (0.64) | LTA4HHRH3POLB | |
| SCHEMBL7819491 | 0.83 | HRH3 (0.62) | HTR2AHRH3HTR1ADRD2DRD1 | |
| SCHEMBL3602514 | 0.82 | LTA4H (0.60) | LTA4HHTR1ADRD2SSTR4 | |
| Hydrochloric Acid SCHEMBL8042992 | 0.82 | HRH3 (0.60) | HTR2AHRH3HTR1ADRD2DRD1 | |
| SCHEMBL9809250 | 0.82 | HRH1 (0.59) | HTR2AHRH3HTR1ADRD2DRD1 | |
| SCHEMBL30437095 | 0.81 | LTA4H (0.56) | LTA4HHTR2ACHRM1MCHR1HRH3 | |
| SCHEMBL19692604 | 0.81 | LTA4H (0.56) | LTA4HHTR2ACHRM1MCHR1HRH3 | |
| SCHEMBL7265514 | 0.81 | LTA4H (0.82) | LTA4HHTR2AMCHR1POLBHTR1A | |
| Hydrochloric Acid SCHEMBL9809406 | 0.81 | HRH1 (0.58) | HTR2AHRH3HTR1ADRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117882-A | 5-HT4 agonists and antagonists | ELI LILLY AND COMPANY (US) | 2000-09-12 | — | — | US | disclosed |
| US-6069152-A | NERVOUS SYSTEM DISORDERS; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS | ELI LILLY AND COMPANY (US) | 2000-05-30 | — | — | US | disclosed |
| US-5959121-A | Process for preparing 3-substituted indazoles | ELI LILLY AND COMPANY (US) | 1999-09-28 | — | — | US | disclosed |
| US-5914405-A | Process for preparing 3-substituted indazoles | ELI LILLY AND COMPANY (US) | 1999-06-22 | — | — | US | disclosed |
| WO-1999017772-A1 | 5HT4 AGONISTS AND ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1999-04-15 | — | — | WO | disclosed |
| WO-1999018080-A1 | PROCESS FOR PREPARING 3-SUBSTITUTED INDAZOLES | ELI LILLY AND COMPANY (US) | 1999-04-15 | — | — | WO | disclosed |
| EP-0908459-A1 | 5-HT4 Agonists and antagonists | ELI LILLY AND COMPANY (US) | 1999-04-14 | — | — | EP | disclosed |
| EP-0908452-A2 | Process for preparing 3-substituted indazoles | ELI LILLY AND COMPANY (US) | 1999-04-14 | — | — | EP | disclosed |