Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | HTR1D | P28221 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 17/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 17/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 6/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420409 | 0.83 | HTR1A (0.53) | HTR1AHTR1DHTR2CITGB3ITGA2B | |
| SCHEMBL7420691 | 0.83 | HTR1A (0.53) | HTR1AHTR1DHTR2CMTNR1AMTNR1B | |
| SCHEMBL6212650 | 0.83 | F10 (0.51) | HTR1AHTR1DHTR2CITGB3ITGA2B | |
| SCHEMBL2640085 | 0.83 | HTR1A (0.47) | HTR1AHTR1DHTR2CITGB3ITGA2B | |
| SCHEMBL6214226 | 0.82 | HTR1A (0.47) | HTR1AHTR1DHTR2CITGB3ITGA2B | |
| SCHEMBL2639933 | 0.82 | CYP1A2 (0.47) | HTR1AHTR1DHTR2CITGB3ITGA2B | |
| SCHEMBL6213779 | 0.82 | HTR1A (0.47) | HTR1AHTR1DHTR2CMTNR1AMTNR1B | |
| SCHEMBL2639713 | 0.81 | HTR1A (0.46) | HTR1AHTR1DHTR2CMTNR1AMTNR1B | |
| SCHEMBL6210723 | 0.81 | HTR1A (0.46) | HTR1AHTR1DHTR2CITGB3ITGA2B | |
| SCHEMBL2640158 | 0.81 | F10 (0.52) | HTR1AHTR1DHTR2CITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222182-A2 | SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL) DIHYDROBENZOFURANS AND BENOZOPYRANS | Aventis Pharmaceuticals Inc. (US) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001014358-A2 | SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL) DIHYDROBENZOFURANS AND BENOZOPYRANS | AVENTIS PHARMACEUTICALS INC. (DE) | 2001-03-01 | — | — | WO | disclosed |