Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.59 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA7 | P43166 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL3 | Q96JM7 | 6/20 | 0.47 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.47 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24185211 | 0.84 | MGLL (0.48) | MGLLCA12CA1CA2CA7 | |
| SCHEMBL6978405 | 0.84 | ACHE (0.63) | MGLLHSD11B1MEN1KMT2AL3MBTL3 | |
| SCHEMBL20116629 | 0.84 | KMT2A (0.61) | MGLLMEN1KMT2AL3MBTL3L3MBTL1 | |
| SCHEMBL23884758 | 0.82 | MGLL (0.46) | MGLLHSD11B1MEN1KMT2AL3MBTL3 | |
| SCHEMBL31267062 | 0.80 | MGLL (0.61) | MGLLCA12CA1CA2CA7 | |
| SCHEMBL3001302 | 0.80 | MGLL (0.61) | MGLLCA12CA1CA2CA7 | |
| SCHEMBL13575475 | 0.80 | MGLL (0.61) | MGLLCA12CA1CA2CA7 | |
| SCHEMBL20261717 | 0.79 | CA12 (0.73) | MGLLCA12CA1CA2CA7 | |
| SCHEMBL12156431 | 0.79 | ACHE (0.70) | MGLLCA12CA1CA2CA7 | |
| SCHEMBL29067078 | 0.78 | MAPT (0.71) | MGLLCA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218372-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | Boehringer Ingelheim Pharmaceuticals, Inc. (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001019816-A1 | NOVEL SPIROHETEROCYCLIC COMPOUNDS USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | disclosed |