Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5799404 | 0.83 | ALDH1A1 (0.47) | MAPTRAB9ANPC1HPGDGSK3B | |
| SCHEMBL27878732 | 0.81 | KMT2A (0.46) | MAPTRAB9AHPGDLMNAKDM4E | |
| SCHEMBL15746272 | 0.78 | ALDH1A1 (0.64) | MAPTRAB9ANPC1HPGDGSK3B | |
| SCHEMBL17212624 | 0.76 | ALDH1A1 (0.63) | MAPTRAB9ANPC1HPGDLMNA | |
| SCHEMBL13623506 | 0.75 | ALDH1A1 (0.49) | MAPTRAB9ANPC1HPGDGSK3B | |
| SCHEMBL866784 | 0.74 | GSK3B (0.61) | MAPTRAB9ANPC1HPGDGSK3B | |
| SCHEMBL4575816 | 0.73 | NPC1 (0.58) | MAPTRAB9ANPC1HPGDGSK3B | |
| SCHEMBL13169508 | 0.72 | PTPRF (0.65) | MAPTRAB9ANPC1LMNAKMT2A | |
| SCHEMBL19318949 | 0.72 | MAPT (0.53) | MAPTRAB9ANPC1HPGDGSK3B | |
| SCHEMBL20054203 | 0.71 | POLB (0.53) | MAPTRAB9AGSK3BHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995004046-A1 | COMPOUNDS AS PDE IV AND TNF INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-02-09 | — | — | WO | disclosed |