SCHEMBL866784

SCHEMBL866784

O=C(COCC(=O)c1ccc(Br)cc1)c1ccc(Br)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 2/20 0.61
NPC1 O15118 1/20 0.59
HPGD P15428 1/20 0.59
RAB9A P51151 1/20 0.59
HDAC1 Q13547 2/20 0.57
HDAC8 Q9BY41 2/20 0.57
HDAC3 O15379 1/20 0.57
HDAC4 P56524 1/20 0.57
HDAC7 Q8WUI4 1/20 0.57
HDAC2 Q92769 1/20 0.57
HDAC10 Q969S8 1/20 0.57
HDAC11 Q96DB2 1/20 0.57
HDAC6 Q9UBN7 1/20 0.57
HDAC9 Q9UKV0 1/20 0.57
HDAC5 Q9UQL6 1/20 0.57
LMNA P02545 2/20 0.56
KDM4E B2RXH2 1/20 0.56
GAA P10253 2/20 0.54
KMT2A Q03164 2/20 0.54
CES2 O00748 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11430938 0.83 GSK3B (0.57) GSK3BNPC1HPGDRAB9AHDAC1
SCHEMBL11430934 0.83 GSK3B (0.57) GSK3BNPC1HPGDRAB9AHDAC1
SCHEMBL7044827 0.82 RAB9A (0.50) GSK3BNPC1HPGDRAB9AHDAC1
SCHEMBL28573354 0.80 HPGD (0.49) GSK3BNPC1HPGDRAB9AHDAC1
SCHEMBL10465722 0.79 GSK3B (0.53) GSK3BNPC1HPGDRAB9AHDAC1
SCHEMBL11801259 0.79 RAB9A (0.62) GSK3BNPC1HPGDRAB9AHDAC1
SCHEMBL11757716 0.79 ALDH1A1 (0.62) GSK3BNPC1HPGDRAB9AHDAC1
SCHEMBL10465723 0.79 GSK3B (0.53) GSK3BNPC1HPGDRAB9AHDAC1
SCHEMBL14735749 0.79 NPC1 (0.58) NPC1RAB9AKDM4EGAAMAPT
SCHEMBL241664 0.78 GSK3B (0.70) GSK3BHDAC1HDAC8HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6703181-B1 COMPRISING AT LEAST ONE OF: IMIDAZOLE COMPOUND, AN ALANINE COMPOUND, AN ADENINE COMPOUND, AN ADENOSINE COMPOUND, AND A QUATERNARY AMMONIUM SALT COMPOUND, AND WHICH INCREASES MISCIBILITY IN A RESIST FILM KABUSHIKI KAISHA TOSHIBA (JP) 2004-03-09 US claimed
US-12551570-B2 Compounds comprising cleavable linker and uses thereof INTOCELL, INC. (KR) 2026-02-17 US disclosed
US-12479927-B2 Compounds comprising cleavable linker and uses thereof INTOCELL, INC. (KR) 2025-11-25 US disclosed
US-20250213712-A1 ANTIBODY DRUG CONJUGATES COMPRISING CAMPTOTHECIN DERIVATIVES AND USES THEREOF INTOCELL, INC. (KR) 2025-07-03 US disclosed
CN-119838020-A Antibody drug conjugates comprising toxins having polar groups and uses thereof 尹图赛利有限公司 2025-04-18 CN disclosed
US-12274898-B2 Substituted benzodiazepines as antibody-drug conjugates INTOCELL, INC. (KR) 2025-04-15 US disclosed
EP-4452328-A1 ANTIBODY DRUG CONJUGATES COMPRISING TOXINS WITH POLAR GROUPS AND USES THEREOF Intocell, Inc. (KR) 2024-10-30 EP disclosed
CN-118414170-A Antibody drug conjugates comprising toxins having polar groups and uses thereof 尹图赛利有限公司 2024-07-30 CN disclosed
US-20230406877-A1 COMPOUNDS COMPRISING CLEAVABLE LINKER AND USES THEREOF INTOCELL, INC. (KR) 2023-12-21 US disclosed
US-11807628-B2 Benzodiazepine derivatives and uses thereof INTOCELL, INC. (KR) 2023-11-07 US disclosed
US-6162614-A Sugar ester derivatives, reagents for measurement of hydrolase activity and methods for measurement of hydrolase activity TOYO BOSEKI KABUSHIKI KAISHA (JP) 2000-12-19 US disclosed
US-5814432-A FORMING RADIATION SENSITIVE LAYER ON SUBSTRATE, CONTAINS FIRST COMPONENT WHICH GENERATES ACID BY CHEMICAL RADIATION AND SECOND COMPONENT THAT HAS BOND BEING DECOMPOSED BY GENERATED ACID KABUSHIKI KAISHA TOSHIBA (JP) 1998-09-29 US disclosed
US-RE35821-E Pattern forming method including the formation of an acidic coating layer on the radiation-sensitive layer KABUSHIKI KAISHA TOSHIBA (JP) 1998-06-09 US disclosed
US-5744281-A P-HYDROXYSTYRENE POLYMER KABUSHIKI KAISHA TOSHIBA (JP) 1998-04-28 US disclosed
EP-0346912-B1 Sugar ester derivatives, reagents for measurement of hydrolase activity and methods for measurement of hydrolase activity TOYO BOSEKI (JP) 1997-12-17 EP disclosed
US-5658706-A CONTAINING COMPOUND WHICH DECOMPOSES INTO AN ACID KABUSHIKI KAISHA TOSHIBA (JP) 1997-08-19 US disclosed
US-5580702-A COMPRISING A PHOTOSENSITIVE ACID-GENERATING COMPOUND AND A COPOLYMER OF P-HYDROXYSTYRENE AND AN ESTER OF P-CARBOXYMETHOXYSTYRENE; NONTOXIC; STEEP WALLS; HIGH SPEED; SEMICONDUCTORS KABUSHIKI KAISHA TOSHIBA (JP) 1996-12-03 US disclosed
US-5403695-A Photolithography; high resolution; semiconductors KABUSHIKI KAISHA TOSHIBA (JP) 1995-04-04 US disclosed
US-5326675-A Pattern forming method including the formation of an acidic coating layer on the radiation-sensitive layer KABUSHIKI KAISHA TOSHIBA (JP) 1994-07-05 US disclosed
EP-0346912-A2 Sugar ester derivatives, reagents for measurement of hydrolase activity and methods for measurement of hydrolase activity Toyo Boseki Kabushiki Kaisha (JP) 1989-12-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11807628-B2 Benzodiazepine derivatives and uses thereof GABRB3, GABRB2, GABRB1 GSK3B 715/4885NPC1 1207/4885HPGD 471/4885
US-20250213712-A1 ANTIBODY DRUG CONJUGATES COMPRISING CAMPTOTHECIN DERIVATIVES AND USES THEREOF CD47, TOP2A, SSB GSK3B 2830/4885NPC1 3651/4885HPGD 1599/4885
US-12551570-B2 Compounds comprising cleavable linker and uses thereof FCGR2A, FCGR3B, FCGR1A GSK3B 4009/4885NPC1 2805/4885HPGD 4856/4885
US-20230406877-A1 COMPOUNDS COMPRISING CLEAVABLE LINKER AND USES THEREOF VIP, ANTXR2, TNFRSF9 GSK3B 4462/4885NPC1 4849/4885HPGD 2968/4885
US-12479927-B2 Compounds comprising cleavable linker and uses thereof VIP, ANTXR2, TNFRSF9 GSK3B 4462/4885NPC1 4849/4885HPGD 2968/4885
US-12274898-B2 Substituted benzodiazepines as antibody-drug conjugates GABRA3, GABRA6, GABRA4 GSK3B 506/4885NPC1 1251/4885HPGD 2221/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.