Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.57 |
| ▸ | PDE4A | P27815 | 11/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416606 | 0.92 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7419008 | 0.89 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7855470 | 0.84 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7855467 | 0.84 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL13350287 | 0.83 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8326534 | 0.83 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL29360419 | 0.83 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL109922 | 0.83 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL9121794 | 0.82 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL11091127 | 0.81 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300372-B1 | USED IN THERAPY OF ALLERGIC AND INFLAMMATORY DISEASES AND FOR INHIBITING THE PRODUCTION OF TUMOR NECROSIS FACTOR (TNF) | SMITHKLINE BEECHAM CORPORATION | 2001-10-09 | — | — | US | disclosed |
| EP-0714293-A4 | 3-CYANO-3-(3,4-DISUBSTITUTED)PHENYLCYCLOHEXYL-1-CARBOXYLATES | SMITHKLINE BEECHAM CORP (US) | 1999-04-07 | — | — | EP | disclosed |
| EP-0714293-A1 | 3-CYANO-3-(3,4-DISUBSTITUTED)PHENYLCYCLOHEXYL-1-CARBOXYLATES | SMITHKLINE BEECHAM CORPORATION (US) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995003794-A1 | 3-CYANO-3-(3,4-DISUBSTITUTED)PHENYLCYCLOHEXYL-1-CARBOXYLATES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-09 | — | — | WO | disclosed |