Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.45 |
| ▸ | FLT3 | P36888 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | CSF1R | P07333 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422251 | 0.80 | PDGFRB (0.67) | KDRPDGFRBSMN1; SMN2ALKMAPT | |
| SCHEMBL5999769 | 0.77 | KDR (0.82) | KDRPDGFRBALKMAPTRET | |
| SCHEMBL5999773 | 0.77 | KDR (0.82) | KDRPDGFRBALKMAPTRET | |
| SCHEMBL7421627 | 0.75 | KDR (0.48) | KDRPDGFRBSMN1; SMN2ALKMAPT | |
| SCHEMBL20338611 | 0.75 | FGFR1 (0.70) | KDRPDGFRBALKRETFGFR1 | |
| SCHEMBL28213543 | 0.74 | CCNB2 (0.57) | KDRPDGFRBSMN1; SMN2MAPTMAPK1 | |
| SCHEMBL5469533 | 0.74 | KDR (1.00) | KDRPDGFRBALKMAPTRET | |
| SCHEMBL5469528 | 0.74 | KDR (1.00) | KDRPDGFRBALKMAPTRET | |
| SCHEMBL1444503 | 0.73 | MAPT (0.54) | KDRPDGFRBSMN1; SMN2ALKMAPT | |
| SCHEMBL1444136 | 0.73 | MAPT (0.54) | KDRPDGFRBSMN1; SMN2ALKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0769947-A4 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN INC (US) | 1998-09-30 | — | — | EP | disclosed |
| EP-0769947-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | Sugen, Inc. (US) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996040116-A1 | INDOLINONE COMPOUNDS FOR THE TREATMENT OF DISEASE | SUGEN, INC. (US) | 1996-12-19 | — | — | WO | disclosed |