Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A1 | P43005 | 4/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10686536 | 0.87 | CYP1A2 (0.43) | SLC1A1SLC1A3SLC1A2KMT2ACYP1A2 | |
| SCHEMBL7415908 | 0.86 | EPOR (0.45) | SLC1A1SLC1A3SLC1A2KMT2ACYP1A2 | |
| SCHEMBL16166282 | 0.85 | SLC1A3 (0.41) | SLC1A1SLC1A3SLC1A2KMT2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL8687105 | 0.85 | EPOR (0.44) | SLC1A1SLC1A3SLC1A2KMT2ACYP1A2 | |
| SCHEMBL6955548 | 0.83 | FOLH1 (0.46) | SLC1A1SLC1A3SLC1A2KMT2ACYP1A2 | |
| SCHEMBL27530431 | 0.83 | CTSB (0.44) | SLC1A1SLC1A3SLC1A2KMT2ACYP1A2 | |
| SCHEMBL7417141 | 0.82 | SLC7A5 (0.42) | SLC1A1SLC1A3SLC1A2KMT2ACYP1A2 | |
| SCHEMBL7515528 | 0.82 | SLC1A3 (0.38) | SLC1A1SLC1A3SLC1A2KMT2ACYP1A2 | |
| SCHEMBL7354777 | 0.82 | MAOB (0.40) | SLC1A1SLC1A3SLC1A2KMT2ACYP1A2 | |
| SCHEMBL10873777 | 0.81 | SLC1A1 (0.45) | SLC1A1SLC1A3SLC1A2KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821241-A | INHIBIT BINDING OF FIBRINOGEN TO BLOOD PLATELETS, INHIBIT AGGREGATION OF BLOOD PLATELETS, PREVENT OR TREAT THROMBUS OR EMBOLUS FORMATION | MERCK & CO., INC. (US) | 1998-10-13 | — | — | US | disclosed |
| EP-0684823-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS. | MERCK & CO INC (US) | 1997-07-09 | — | — | EP | disclosed |
| EP-0684823-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1995-12-06 | — | — | EP | disclosed |
| WO-1994018981-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1994-09-01 | — | — | WO | disclosed |