Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | PPARA | Q07869 | 3/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8910551 | 0.88 | PTGES (0.42) | PPARG | |
| SCHEMBL6955548 | 0.85 | FOLH1 (0.46) | SLC1A3SLC1A2SLC1A1MEN1CYP1A2 | |
| SCHEMBL10686536 | 0.83 | CYP1A2 (0.43) | SLC1A3SLC1A2SLC1A1MEN1CYP1A2 | |
| SCHEMBL16166282 | 0.82 | SLC1A3 (0.41) | SLC1A3SLC1A2SLC1A1MEN1CYP1A2 | |
| SCHEMBL7420915 | 0.82 | SLC1A1 (0.44) | SLC1A3SLC1A2SLC1A1MEN1CYP1A2 | |
| SCHEMBL57730 | 0.82 | FOLH1 (0.39) | SLC1A3SLC1A2SLC1A1MEN1CYP1A2 | |
| SCHEMBL56607 | 0.81 | FOLH1 (0.38) | SLC1A3SLC1A2SLC1A1MEN1CYP1A2 | |
| SCHEMBL6299671 | 0.81 | ALDH1A1 (0.43) | SLC1A3SLC1A2SLC1A1MEN1CYP1A2 | |
| SCHEMBL6298147 | 0.81 | ALDH1A1 (0.43) | SLC1A3SLC1A2SLC1A1MEN1CYP1A2 | |
| SCHEMBL7100804 | 0.80 | HPGD (0.40) | MEN1CYP2C9CYP2C19KMT2AFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641800-B1 | Lactol derivatives as inhibitors of cathepsin L | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-16 | — | — | EP | disclosed |
| US-5496834-A | PEPTIDE DERIVATIVES AS CATHEPSIN L INHIBITORS AND INHIBITORS OF BONE RESORPTION OR TREATMENT OF OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0641800-A1 | Lactol derivatives as inhibiters of cathepsin L | Takeda Chemical Industries, Ltd. (JP) | 1995-03-08 | — | — | EP | disclosed |