Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.56 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.56 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.56 |
| ▸ | F2 | P00734 | 13/20 | 0.55 |
| ▸ | TMPRSS6 | Q8IU80 | 7/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986314 | 0.87 | F10 (0.53) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL7423694 | 0.85 | RAB9A (0.56) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL7389439 | 0.84 | RAB9A (0.55) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL7982625 | 0.84 | RAB9A (0.55) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL7986111 | 0.83 | RAB9A (0.54) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL7986806 | 0.83 | RAB9A (0.54) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL7984063 | 0.83 | RAB9A (0.54) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL10035190 | 0.82 | HTT (0.58) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL7538755 | 0.78 | PRSS1 (0.59) | F10PRSS1PRSS2PRSS3F2 | |
| SCHEMBL15555895 | 0.78 | TMPRSS6 (0.55) | F10PRSS1PRSS2PRSS3F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221914-B1 | ANTIINFLAMMATORY AGENTS | ARRAY BIOPHARMA INC. | 2001-04-24 | — | — | US | disclosed |
| WO-1999024395-A1 | COMPOUNDS WHICH INHIBIT TRYPTASE ACTIVITY | ARRAY BIOPHARMA, INC. (US) | 1999-05-20 | — | — | WO | disclosed |