Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 4/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 4/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 4/20 | 1.00 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419331 | 0.92 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL7424183 | 0.88 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL13350317 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL7425456 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL7418696 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL7421227 | 0.81 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL7418335 | 0.81 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL7423655 | 0.80 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DCA1 | |
| SCHEMBL7470631 | 0.79 | PDE4A (0.87) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL7477667 | 0.79 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036596-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |
| WO-1996036596-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |