Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.47 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | JAK1 | P23458 | 4/20 | 0.39 |
| ▸ | TYK2 | P29597 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7432930 | 0.79 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DJAK2 | |
| SCHEMBL4698112 | 0.77 | PDE4D (0.77) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL7977878 | 0.77 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DJAK2 | |
| SCHEMBL7982474 | 0.74 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DJAK2 | |
| SCHEMBL4701753 | 0.73 | PDE4B (0.43) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4699328 | 0.68 | PDE4D (0.69) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL4703070 | 0.66 | PDE4D (0.75) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL7976353 | 0.65 | PDE4B (0.52) | PDE4APDE4BPDE4CPDE4DPDE11A | |
| SCHEMBL7979774 | 0.65 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DJAK2 | |
| SCHEMBL4698780 | 0.64 | PDE4D (1.00) | PDE4APDE4BPDE4CPDE4DPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045845-A1 | N-OXIDES OF HETEROCYCLIC COMPOUNDS WITH TNF AND PDE-IV INHIBITING ACTIVITY | Darwin Discovery Limited (GB) | 2000-10-25 | — | — | EP | claimed |
| WO-2000026208-A1 | N-OXIDES OF HETEROCYCLIC COMPOUNDS WITH TNF AND PDE-IV INHIBITING ACTIVITY | DARWIN DISCOVERY LIMITED (GB) | 2000-05-11 | — | — | WO | claimed |