Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.48 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982474 | 0.91 | PDE4A (0.43) | PDE4APDE4DPDE4BPDE4CPDE11A | |
| SCHEMBL7979774 | 0.88 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4CPDE11A | |
| SCHEMBL7432930 | 0.82 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE4CPDE11A | |
| SCHEMBL7976353 | 0.81 | PDE4B (0.52) | PDE4APDE4DPDE4BPDE4CPDE11A | |
| SCHEMBL4698112 | 0.79 | PDE4D (0.77) | PDE4APDE4DPDE4BPDE4CPDE11A | |
| SCHEMBL7982313 | 0.79 | PDE4B (0.70) | PDE4APDE4DPDE4BPDE4CPDE11A | |
| SCHEMBL7421111 | 0.77 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4CPDE11A | |
| SCHEMBL12371963 | 0.76 | PDE4D (0.77) | PDE4APDE4DPDE4BPDE4CPDE11A | |
| SCHEMBL7982342 | 0.76 | PDE4D (0.64) | PDE4APDE4DPDE4BPDE4CPDE11A | |
| SCHEMBL4701753 | 0.73 | PDE4B (0.43) | PDE4APDE4DPDE4BPDE4CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262070-B1 | E.G., 8-METHOXY-2-TRIFLUOROMETHYLQUINOLINE-5-CARBOXYLIC ACID(3,5-DICHLORO-1-OXYPYRIDIN-4-YL)AMIDE; TREATMENT OF CHRONIC OBSTRUCTIVE AIRWAYS DISEASE | DARWIN DISCOVERY LTD. (GB) | 2001-07-17 | — | — | US | claimed |