Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 15/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.82 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinaprilat SCHEMBL11306348 | 1.00 | ACE (1.00) | ACEABCB11PDE3A | |
| Quinaprilat SCHEMBL7392611 | 1.00 | ACE (1.00) | ACEABCB11PDE3A | |
| Quinaprilat SCHEMBL11286565 | 1.00 | ACE (1.00) | ACEABCB11PDE3A | |
| Quinaprilat SCHEMBL113237 | 1.00 | ACE (1.00) | ACEABCB11PDE3A | |
| Quinaprilat SCHEMBL6438000 | 1.00 | ACE (1.00) | ACEABCB11PDE3A | |
| Quinaprilat SCHEMBL29598971 | 1.00 | ACE (1.00) | ACEABCB11PDE3A | |
| Quinaprilat SCHEMBL11286571 | 1.00 | ACE (1.00) | ACEABCB11PDE3A | |
| Quinaprilat SCHEMBL9253792 | 1.00 | ACE (1.00) | ACEABCB11PDE3A | |
| Quinaprilat SCHEMBL27697059 | 0.99 | ACE (0.98) | ACEABCB11PDE3A | |
| Quinaprilat SCHEMBL27717008 | 0.99 | ACE (0.98) | ACEABCB11PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4584299-A | MIXTURE OF HYPOTENSIVE AND CARDIOTONIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1986-04-22 | — | — | US | claimed |
| US-4344949-A | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids | WARNER-LAMBERT COMPANY (US) | 1982-08-17 | — | — | US | claimed |
| EP-0049605-A1 | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids, salts thereof, pharmaceutical compositions containing the derivatives or salts, and the production of the same | WARNER-LAMBERT COMPANY (US) | 1982-04-14 | — | — | EP | claimed |
| EP-1028728-A1 | USE OF QUINAPRIL FOR TREATING MYOCARDIAL ISCHEMIA AND ANGINA | WARNER-LAMBERT COMPANY (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999022736-A1 | USE OF QUINAPRIL FOR TREATING MYOCARDIAL ISCHEMIA AND ANGINA | WARNER-LAMBERT COMPANY (US) | 1999-05-14 | — | — | WO | disclosed |
| EP-0049605-B1 | SUBSTITUTED ACYL DERIVATIVES OF 1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACIDS, SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES OR SALTS, AND THE PRODUCTION OF THE SAME | WARNER-LAMBERT COMPANY (US) | 1987-03-18 | — | — | EP | disclosed |
| US-4584299-A | MIXTURE OF HYPOTENSIVE AND CARDIOTONIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1986-04-22 | — | — | US | disclosed |
| US-4532342-A | N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids | WARNER-LAMBERT COMPANY (US) | 1985-07-30 | — | — | US | disclosed |
| US-4344949-A | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids | WARNER-LAMBERT COMPANY (US) | 1982-08-17 | — | — | US | disclosed |
| EP-0049605-A1 | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids, salts thereof, pharmaceutical compositions containing the derivatives or salts, and the production of the same | WARNER-LAMBERT COMPANY (US) | 1982-04-14 | — | — | EP | disclosed |