Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.81 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.81 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.81 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.81 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.45 |
| ▸ | EP300 | Q09472 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413548 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7423546 | 0.86 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7418078 | 0.80 | PDE4D (1.00) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7422584 | 0.80 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7418801 | 0.77 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL7423419 | 0.77 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7423898 | 0.76 | PDE4D (0.64) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7423896 | 0.74 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DTAS2R14 | |
| SCHEMBL7421632 | 0.73 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL5518164 | 0.69 | PSEN1 (0.72) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996036596-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | claimed |
| WO-1996036596-A1 | 3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1996-11-21 | — | — | WO | disclosed |