Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | REN | P00797 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | ACP1 | P24666 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740862 | 0.88 | CHRM1 (0.46) | CHRM1HRH1RENOPRM1OPRD1 | |
| SCHEMBL737976 | 0.81 | HRH1 (0.55) | CHRM1HRH1RENOPRM1OPRD1 | |
| SCHEMBL737977 | 0.81 | HRH1 (0.55) | CHRM1HRH1RENOPRM1OPRD1 | |
| SCHEMBL739843 | 0.80 | HRH1 (0.70) | CHRM1HRH1RENOPRM1OPRD1 | |
| SCHEMBL739842 | 0.80 | HRH1 (0.70) | CHRM1HRH1RENOPRM1OPRD1 | |
| SCHEMBL739358 | 0.79 | CHRM1 (0.53) | CHRM1HRH1RENOPRM1OPRD1 | |
| SCHEMBL739357 | 0.79 | CHRM1 (0.53) | CHRM1HRH1RENOPRM1OPRD1 | |
| SCHEMBL742774 | 0.79 | HRH1 (0.54) | CHRM1HRH1RENOPRM1OPRD1 | |
| SCHEMBL742773 | 0.79 | HRH1 (0.54) | CHRM1HRH1RENOPRM1OPRD1 | |
| SCHEMBL740755 | 0.79 | HRH1 (0.52) | CHRM1HRH1RENOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |